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Teva

for HD Chorea in Adults1

IMPORTANT SAFETY INFORMATION

AUSTEDO (deutetrabenazine) tablets can cause serious side effects in people with Huntington’s disease, including: depression, suicidal thoughts, or suicidal actions. Do not start taking AUSTEDO if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when AUSTEDO is started and when the dose is changed. Call your healthcare provider right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of suicide. Please see additional Important Safety Information below.

90% of people living with HD develop chorea2

If you recognize these symptoms or notice difficulty performing everyday activities, tell your doctor so you can discuss treatment options.3,4,5

Flicking the fingers
Flailing of the arms or legs
Shrugging the shoulders
Having a grimacing look
Twisting or jerking
Irregular eye movements or blinking

Navigating life with HD chorea can be difficult, but many people find ways to preserve as much independence as possible for as long as possible.6

Talking with your doctor

Experiencing HD chorea symptoms? Use this guide to help start a conversation at your next doctor’s appointment about whether AUSTEDO might be right for you.

Get the guide

In a clinical study,

AUSTEDO tablets significantly reduced Huntington’s disease (HD) chorea

In a 12-week study, people taking AUSTEDO saw >2x reduction in HD chorea movements vs placebo1*

*4.4-point improvement in people taking AUSTEDO vs 1.9 in people taking placebo based on Total Maximal Chorea (TMC) score. The TMC score is used to measure HD chorea movements in the face, mouth, trunk, both arms, and both legs.

Overall improvement with AUSTEDO

AUSTEDO is the first and only HD chorea treatment to have both patients and doctors rate overall HD symptoms as “much improved” or “very much improved” at 12 weeks.1,7

For additional information about AUSTEDO and how to talk to your doctor, download our resources or register to get information sent to your inbox.

DOWNLOAD RESOURCES | REGISTER TO LEARN MORE

APPROVED USES

AUSTEDO is a prescription medicine that is used to treat:

  • the involuntary movements (chorea) of Huntington’s disease. AUSTEDO does not cure the cause of the involuntary movements, and it does not treat other symptoms of Huntington’s disease, such as problems with thinking or emotions.
  • movements in the face, tongue, or other body parts that cannot be controlled (tardive dyskinesia).

It is not known if AUSTEDO is safe and effective in children.

IMPORTANT SAFETY INFORMATION

AUSTEDO can cause serious side effects in people with Huntington’s disease, including: depression, suicidal thoughts, or suicidal actions.

Do not start taking AUSTEDO if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when AUSTEDO is started and when the dose is changed. Call your healthcare provider right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of suicide.

Do not take AUSTEDO if you:
  • have Huntington’s disease and are depressed or have thoughts of suicide.
  • have liver problems.
  • are taking a monoamine oxidase inhibitor (MAOI) medicine. Do not take an MAOI within 14 days after you stop taking AUSTEDO. Do not start AUSTEDO if you stopped taking an MAOI in the last 14 days. Ask your healthcare provider or pharmacist if you are not sure.
  • are taking reserpine. Do not take medicines that contain reserpine (such as Serpalan® and Renese®-R) with AUSTEDO. If your healthcare provider plans to switch you from taking reserpine to AUSTEDO, you must wait at least 20 days after your last dose of reserpine before you start taking AUSTEDO.
  • are taking tetrabenazine (Xenazine®). If your healthcare provider plans to switch you from tetrabenazine (Xenazine®) to AUSTEDO, take your first dose of AUSTEDO on the day after your last dose of tetrabenazine (Xenazine®).
  • are taking valbenazine (Ingrezza®).
Other possible serious side effects include:
  • Irregular heartbeat (QT prolongation). AUSTEDO increases your chance of having certain changes in the electrical activity in your heart. These changes can lead to a dangerous abnormal heartbeat. Taking AUSTEDO with certain medicines may increase this chance.
  • Neuroleptic Malignant Syndrome. Call your healthcare provider right away and go to the nearest emergency room if you develop these signs and symptoms that do not have another obvious cause: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, or increased sweating.
  • Restlessness. You may get a condition where you feel a strong urge to move. This is called akathisia.
  • Parkinsonism. Symptoms include: slight shaking, body stiffness, trouble moving, trouble keeping your balance, or falls.

Sleepiness (sedation) is a common side effect of AUSTEDO. While taking AUSTEDO, do not drive a car or operate dangerous machinery until you know how AUSTEDO affects you. Drinking alcohol and taking other drugs that may also cause sleepiness while you are taking AUSTEDO may increase any sleepiness caused by AUSTEDO.

The most common side effects of AUSTEDO in people with Huntington’s disease include sleepiness (sedation), diarrhea, tiredness, and dry mouth.

The most common side effects of AUSTEDO in people with tardive dyskinesia include inflammation of the nose and throat (nasopharyngitis) and problems sleeping (insomnia).

These are not all the possible side effects of AUSTEDO. Call your doctor for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please read the Medication Guide.

The brands listed are registered trademarks of their respective owners

Reference: 1. AUSTEDO® (deutetrabenazine) tablets current Prescribing Information Parsippany, NJ. Teva Neuroscience, Inc. 2. Thorley EM, Iyer RG, Wicks P, et al. Understanding how chorea affects health-related quality of life in Huntington disease: an online survey of patients and caregivers in the United States. Patient. 2018;11(5):547-559. doi:10.1007/s40271-018-0312-x 3. Huntington’s disease: hope through research. National Institute of Neurological Disorders and Stroke. Updated April 18, 2022. Accessed January 28, 2020. https://www.ninds.nih.gov/health-information/patient-caregiver-education/hope-through-research/huntingtons-disease-hope-through-research 4. Burgess, JC, Davis B, Fogarty E, et al. Caregiver Guide for Mid to Late Stage Huntington’s Disease: For Long-Term Care Facilities and In-Home Care Agencies. Huntington’s Disease Society of America; 2014. Accessed May 12, 2022. https://hdsa.org/wp-content/uploads/2015/04/CaregiverGuide_Mid_Late_StageHD.pdf 5. Caron NS, Wright GEB, Hayden MR. Huntington disease: Synonym: Huntington chorea. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, eds. GeneReviews. University of Washington, Seattle; 1993-2018. 6. Overview of Huntington’s disease. Huntington’s Disease Society of America. Accessed February 23, 2022. https://hdsa.org/what-is-hd/overview-of-huntingtons-disease/ 7. Data on file. Parsippany, NJ: Teva Neuroscience, Inc.

© 2022 Teva Neuroscience, Inc.
AUS-44469 May 2022