Xiangrui Zeng, PhD
Research Fellow, Massachusetts General Hospital , Drs. Diana Rosas, Bruce Fischl, and Juan Iglesias
Integrating clinical MRI and ultra-high resolution ex vivo MRI to model laminar anomaly progression in Huntington's disease
The cerebral cortex, often referred to as the “shell” of the human brain, contains multiple layers. These layers become damaged sequentially over time in HD, but a better understanding of this process holds therapeutic potential. Dr. Zeng will work with Drs. Diana Rosas, Bruce Fischl, and Juan Iglesias to apply new AI tools to detect the shape and thickness of brain layers from existing MRI scans, towards the goal of building detailed models describing how HD progresses inside the brain.