Tamara Maiuri, PhD

, Ray Truant, PhD

Poly ADP-ribose dysregulation in HD patient samples and potential for therapeutic intervention

Thanks to the participation of thousands of HD patients in clinical studies, we now know that it may be possible to delay disease onset by targeting DNA repair pathways. Our research group has found that the huntingtin protein is involved in a step of the DNA repair process called poly ADP-ribosylation. Drugs targeting this step have been developed for cancer treatment, but we do not yet know whether it makes sense to repurpose these drugs for HD.This project will carry out preclinical analysis to explore this potential therapeutic avenue.