Lea Danics, PhD

Postdoc, Semmelweis University, Mentor: Karolina Pircs, PhD

Identification of novel targets with therapeutic potential in HD using a patient-derived induced neuronal model

This project will explore the use of a novel model system in which human skin cells donated by people with HD can be directly converted in a dish into brain cells, retaining properties of the donors in a way that better reflects the adult onset of HD. This process will enable Dr. Danics to investigate new therapeutic targets within the biological pathways that control the breakdown of toxic huntingtin, which could be applied to drug development. To date, this has been difficult to achieve in systems that don’t accurately reflect human aging.