Kilian Hett, PhD

Postdoctoral Research Fellow, Vanderbilt University Medical Center, Mentor: Daniel Claassen, MD

Cerebrospinal fluid in glymphatic circuit in Huntington's disease

This study will use use non-invasive MRI technology to investigate HD-related changes in the circulation of the fluid that bathes the nervous system, known as cerebrospinal fluid (CSF). By measuring the flow of CSF in people, Dr. Hett will attempt to understand better how it changes with HD, and, as a result, potentially determine how drug delivery methods might be tailored more personally. This novel idea emerged from a small pilot study, but could have major implications for the delivery of huntingtin-lowering therapies.