Ines Bras, PhD
Postdoctoral Scholar, University of Central Florida, Mentor: Amber Southwell, PhD
Extracellular vesicles as non-invasive biomarkers for Huntington disease progression and huntingtin lowering therapy
This project focuses on the development of a novel biomarker, measured in human blood. If successful, it will represent a new and less invasive way to track HD progression and the effectiveness of huntingtin-lowering therapies over the duration of a clinical trial. Dr. Bras has shown that huntingtin protein can be found in extracellular vesicles, small sacs that are shed from brain cells. Over the course of this project, she will refine techniques for detecting these vesicles in blood donated by people with HD.